Umer, M J and Lu, Q and Huang, L and Batool, R and Liu, H and Li, H and Wang, R and Qianxia, Y and Varshney, R K and Pandey, M K and Hong, Y and Chen, X (2024) Genome-wide association study reveals the genetic basis of amino acids contents variations in Peanut (Arachis hypogaea L.). Physiologia Plantarum (TSI), 176 (5). pp. 1-18. ISSN 0031-9317
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Abstract
Peanut is a significant source of protein for human consumption. One of the primary objectives in peanut breeding is the development of new cultivars with enhanced nutritional values. To further this goal, a genome-wide association study (GWAS) was conducted to analyze seed amino acids contents in 390 diverse peanut accessions collected worldwide, mainly from China, India, and the United States, in 2017 and 2018. These accessions were assessed for their content of 10 different amino acids. Variations in amino acids contents were observed, and arginine (Arg) was found to have the highest average value among all the amino acids quantified. The geographical distribution of the accessions also revealed variations in amino acids contents. High and positive correlation coefficients were observed among the amino acids, suggesting linked metabolic pathways or genetic regulation. A total of 88 single nucleotide polymorphisms (SNPs) spanning various chromosomes were identified, each associated with different amino acids. By using a combination of GWAS, expression anlaysis, and genomic polymorphisim comparisions, the Ahy_A09g041582 (LAC15) gene located on chromrosome A09 was identified as the key candidate which might be involved in plant growth and regulation and may alter amino acids levels. Expression analysis indicated that Ahy_A09g041582 has higher expressions in the shells and seeds than other genes located in the candidate region. This study may help with marker-based breeding of peanuts with higher nutritional value and offers fresh insights into the genetic basis of the amino acids contents of peanuts.
| Item Type: | Article |
|---|---|
| Divisions: | Center of Excellence in Genomics and Systems Biology |
| CRP: | UNSPECIFIED |
| Uncontrolled Keywords: | amino acids, peanut, Genome-wide association study, genetics |
| Subjects: | Mandate crops > Groundnut Others > Genetics and Genomics |
| Depositing User: | Mr Nagaraju T |
| Date Deposited: | 23 Apr 2025 11:15 |
| Last Modified: | 23 Apr 2025 11:15 |
| URI: | http://oar.icrisat.org/id/eprint/13046 |
| Official URL: | https://onlinelibrary.wiley.com/doi/epdf/10.1111/p... |
| Projects: | UNSPECIFIED |
| Funders: | UNSPECIFIED |
| Acknowledgement: | This work was supported by the National Natural Science Foundation of China (32172051 and 32301869), the National Key R&D Program of China (2023YFD1202800), China Agriculture Research System of MOF and MARA (CARS-13), the Open Competition Program of Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan in Guangdong Province (2022SDZG05), Guangdong Provincial Key Research and Development Program-Modern Seed Industry (2022B0202060004), Guangdong Science and Technology Plan Project (2023B1212060038), Guangdong Basic and Applied Basic Research Foundation (2023A1515010098), the Special Support Program of Guangdong Province (2021TX06N789), Guangzhou Basic and Applied Basic Research Foundation (202201010281 and 2023A04J0776), Special Fund for High Level Academy of Agriculture Science (R2020PY-JX004, R2020PY-JG005, R2021PY-QY003,R2022YJ-YB3025 and R2023PY-JG007), the Foundation of Director of Crop Research Institute of Guangdong Academy of Agriculture Sciences (202101, 202201 and 202306), the Project of Collaborative Innovation Center of GDAAS(XTXM202203). |
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