Ghosh, S and Palika, R and Dasi, T and Varshney, R K and Parasannanavar, D J and Gupta, S S and Chitikineni, A and Banjara, S K and Pullakhandam, R and Thomas, T and Sachdev, H S and Kurpad, A V and Kulkarni, B (2023) Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age. European Journal of Clinical Nutrition, 77. pp. 966-971. ISSN 1476-5640
Full text not available from this repository. (Request a copy)Abstract
Background The persistent high prevalence of anaemia among Indian women of reproductive age (WRA) despite aggressive long-term iron supplementation could be related to over-diagnosis from an inappropriately high haemoglobin (Hb) diagnostic cut-off. To develop an appropriate cut-off for Indian WRA, we hypothesized that during iron-folic acid (IFA) supplementation to a mixed (anaemic/non-anaemic) WRA population, the positive slope of the Hb-plasma ferritin (PF) response in anaemic women would inflect into a plateau (zero-response) as a non-anaemic status is reached. The 2.5th percentile of the Hb distribution at this inflection point will be the diagnostic Hb cut-off for iron-responsive anaemia. Method A hierarchical mixed effects model, with a polynomial mean and variance model to account for intraclass correlation due to repeated measures, was used to estimate the response curve of Hb to PF, or body iron stores, in anaemic and non-anaemic WRA (without inflammation), who were receiving a 90-day IFA supplementation. Results The Hb response curve at low PF values showed a steep increase, which inflected into a plateau at a PF of 10.1 µg/L and attained a steady state at a PF of 20.6 µg/L. The Hb distribution at the inflection was a normal probability distribution, with a mean of 12.3 g/dL. The 2.5th percentile value of this distribution, or the putative diagnostic Hb cut-off for anaemia, was 10.8 g/dL (~11 g/dL). Conclusion The derived Hb cut-off is lower than the current adult values of 12 g/dL and could partly explain the persistently high prevalence of anaemia.
| Item Type: | Article |
|---|---|
| Divisions: | Center of Excellence in Genomics and Systems Biology |
| CRP: | UNSPECIFIED |
| Uncontrolled Keywords: | Nutrition, Public health |
| Subjects: | Others > Food and Nutrition |
| Depositing User: | Mr Nagaraju T |
| Date Deposited: | 01 Feb 2024 06:12 |
| Last Modified: | 01 Feb 2024 06:12 |
| URI: | http://oar.icrisat.org/id/eprint/12414 |
| Official URL: | https://www.nature.com/articles/s41430-023-01308-5 |
| Projects: | UNSPECIFIED |
| Funders: | UNSPECIFIED |
| Acknowledgement: | This secondary analysis was not funded. The human data came from a study that was funded by the Indian Council of Medical Research (ICMR), Government of India to BK, in turn nested in a larger study supported by a grant from the Systems Biology Research Initiative from the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) to RKV. The ICRISAT funding contributed to some activities related to data collection in the present study. |
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