Genome-Wide Association Studies and Genomic Selection in Pearl Millet: Advances and Prospects

Srivastava, R K and Singh, R B and Pujarula, V L and Bollam, S and Pusuluri, M and Chellapilla, T S and Yadav, R S and Gupta, R (2020) Genome-Wide Association Studies and Genomic Selection in Pearl Millet: Advances and Prospects. Frontiers in Genetics (TSI), 10 (1389). pp. 1-10. ISSN 1664-8021

PDF - Published Version Download (2MB)

Abstract

Pearl millet is a climate-resilient, drought-tolerant crop capable of growing in marginal environments of arid and semi-arid regions globally. Pearl millet is a staple food for more than 90 million people living in poverty and can address the triple burden of malnutrition substantially. It remained a neglected crop until the turn of the 21st century, and much emphasis has been placed since then on the development of various genetic and genomic resources for whole-genome scan studies, such as the genome-wide association studies (GWAS) and genomic selection (GS). This was facilitated by the advent of sequencingbased genotyping, such as genotyping-by-sequencing (GBS), RAD-sequencing, and whole-genome re-sequencing (WGRS) in pearl millet. To carry out GWAS and GS, a world association mapping panel called the Pearl Millet inbred Germplasm Association Panel (PMiGAP) was developed at ICRISAT in partnership with Aberystwyth University. This panel consisted of germplasm lines, landraces, and breeding lines from 27 countries and was re-sequenced using the WGRS approach. It has a repository of circa 29 million genome-wide SNPs. PMiGAP has been used to map traits related to drought tolerance, grain Fe and Zn content, nitrogen use efficiency, components of endosperm starch, grain yield, etc. Genomic selection in pearl millet was jump-started recently by WGRS, RAD, and tGBS (tunable genotyping-by-sequencing) approaches for the PMiGAP and hybrid parental lines. Using multi-environment phenotyping of various training populations, initial attempts have been made to develop genomic selection models. This mini review discusses advances and prospects in GWAS and GS for pearl millet.

Item Type:	Article
Divisions:	Research Program : Genetic Gains
CRP:	CGIAR Research Program on Grain Legumes and Dryland Cereals (GLDC)
Uncontrolled Keywords:	Pearl millet, Genetic resources, Genomic resources, Genomic selection, Genome-wide Association studies, Molecular markers
Subjects:	Others > Drought Tolerance Mandate crops > Millets > Pearl Millet Others > Genetics and Genomics Others > Food and Nutrition
Depositing User:	Mr Arun S
Date Deposited:	19 May 2020 09:02
Last Modified:	19 May 2020 09:04
URI:	http://oar.icrisat.org/id/eprint/11511
Official URL:	https://doi.org/10.3389/fgene.2019.01389
Projects:	UNSPECIFIED
Funders:	UNSPECIFIED
Acknowledgement:	Funding support from the Department of Biotechnology (DBT), Government of India, the Biotechnology and Biological Sciences Research Council (BBSRC), United Kingdom, and the CGIAR Research Program on Grain Legumes and Dryland Cereals (CRP-GLDC) is gratefully acknowledged. This work has been published as part of the CRP-GLDC.
Links:	Google Scholar

View Statistics

Actions (login required)

View Item