eprintid: 748
rev_number: 8
eprint_status: archive
userid: 14
dir: disk0/00/00/07/48
datestamp: 2011-10-07 05:48:52
lastmod: 2014-11-05 07:55:29
status_changed: 2011-10-07 05:48:52
type: article
metadata_visibility: show
contact_email: Library-ICRISAT@cgiar.org
item_issues_count: 0
creators_name: Kiambi, D K
creators_name: Fortin, M
creators_name: Stromvick, M
icrisatcreators_name: Kiambi, D K
affiliation: ICRISAT(Nairobi)
affiliation: Department of Plant Science(McGill University)
country: Kenya
country: Canada
title: Linking transcript profiles to metabolites and metabolic pathways: a systems biology approach to transgene risk assessment
ispublished: pub
subjects: s2.4
full_text_status: public
abstract: In recent years, questions related to molecular composition and its implications for nutrition and health have been raised as advances in technology speed up the introduction of new diversity into breeding programs, either via transgenic technology or by using molecular markers in combination with wide crosses. Metabolite profiling offers great opportunities for characterization of this diversity phenotypically with respect to its metabolite composition. It provides a powerful resource to guide breeding programs and to alert researchers to positive or detrimental traits at an early stage. The power of this approach will be vastly increased by combining it with transcript profiling and a systematic survey of the metabolite composition of the plant products that are already on the market. This integrated approach and holistic profiling within a systems biology approach enables the careful tracking of the response of the organism to conditional perturbations at different molecular and genetic levels using available databases. This approach to profiling will not only provide a baseline for comparison of plants with novel traits (PNTs) with traditional comparators that are 'generally recognized as safe', but also provide a rational framework for risk assessment via 'substantial equivalence'. It also provides important inputs into nutritional research and contributes to the public debate about the acceptability of changes in food-production chains and development of science based regulation of plants with novel traits.
date: 2008
date_type: published
publication: Plant Omics Journal
volume: 1
number: 1
pagerange: 26-36
refereed: TRUE
issn: 1836-3644
related_url_url: http://scholar.google.co.in/scholar?as_q=Linking+transcript+profiles+to+metabolites+and+metabolic+pathways%3A+a+systems+biology+approach+to+transgene+risk+assessment&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=title&as_sauthors=&as_publicatio
related_url_type: author
citation:   Kiambi, D K and Fortin, M and Stromvick, M  (2008) Linking transcript profiles to metabolites and metabolic pathways: a systems biology approach to transgene risk assessment.  Plant Omics Journal, 1 (1).  pp. 26-36.  ISSN 1836-3644     
document_url: http://oar.icrisat.org/748/1/Plant_Omics_1%2826-36%29_2008.pdf