TY  - JOUR
AV  - public
A1  - Morris, G P
A1  - Ramu, P
A1  - Desphande, S
A1  - Hash, C T
A1  - Shah, T
A1  - Upadhyaya, H D
A1  - Riera-Lizarazu, O
A1  - Brown, P J
A1  - Acharjee, C B
A1  - Mitchell, S E
A1  - Harriman, J
A1  - Glaubitz, J C
A1  - Buckler, E S
A1  - Kresovich, S
TI  - Population genomic and genome-wide association studies of agroclimatic traits in sorghum
UR  - http://dx.doi.org/10.1073/pnas.1215985110 
JF  - Proceedings of the National Academy of Sciences
SN  - 1091-6490
PB  - National Academy of Sciences
N1  - We thank two anonymous reviewers for helpful comments.
This work was also supported by Department of Agriculture-
National Institute of Food and Agriculture Plant Feedstock Genomics for Bioenergy Program Grant 2011-03502 (to S.K.).

Supporting Information: http://www.pnas.org/content/suppl/2012/12/19/1215985110.DCSupplemental
N2  - Accelerating crop improvement in sorghum, a staple food for people in semiarid regions across the developing world, is key to ensuring global food security in the context of climate change. To facilitate gene discovery and molecular breeding in sorghum, we have characterized ?265,000 single nucleotide polymorphisms (SNPs) in 971 worldwide accessions that have adapted to diverse agroclimatic conditions. Using this genome-wide SNPmap,we have characterized population structure with respect to geographic origin and  morphological type and identified patterns of ancient crop diffusion to diverse agroclimatic regions across Africa and Asia. To better understand the genomic patterns of diversification in sorghum, we quantified variation in nucleotide diversity, linkage disequilibrium, and
recombination rates across the genome. Analyzing nucleotide diversity in landraces, we find evidence of selective sweeps around starch metabolism genes, whereas in landrace-derived introgression lines, we find introgressions around known height and maturity loci. To identify additional loci underlying variation in major agroclimatic traits, we performed genome-wide association studies (GWAS) on
plant height components and inflorescence architecture. GWAS maps several classical loci for plant height, candidate genes for inflorescence architecture. Finally, we trace the independent spread of multiple haplotypes carrying alleles for short stature or long inflorescence branches. This genome-wide map of SNP variation in sorghum provides
a basis for crop improvement through marker-assisted breeding and genomic selection.
KW  - Sorghum bicolor
KW  - Quantitative trait locus
KW  -  Adaptation
Y1  - 2013///
SP  - 453
ID  - icrisat6357
EP  - 458
VL  - 110
IS  - 2
ER  -