<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Assessment of Aflatoxin Exposure among Indian Population"^^ . "What impact does dietary exposure to aflatoxins has on hepatocellular carcinoma\r\nin India? Assessing the connection between aflatoxin contamination in the diets,\r\nHepatitis B virus infection and liver cirrhosis through Hospital based study in\r\nAndhra Pradesh, India\r\nChronic exposure to aflatoxins was shown to cause impaired growth in children,\r\nimmune suppression and liver cirrhosis, interference in micronutrient metabolism and\r\nreduced human and animal productivity. Acute severe intoxication can result in death.\r\nMost importantly, aflatoxin was shown to interact synergistically with Hepatitis B\r\nvirus (HBV) / Hepatitis C virus infection. It increases the risk of hepatocellular\r\ncarcinoma (HCC), one of the most common cancers in the developing countries with\r\n>400,000 new cases per annum. A joint FAO and WHO committee concluded that\r\nreduced intake of aflatoxins in HBV endemic places will have a greater impact on\r\nreducing the incidence of HCC. This requires knowledge on the level of aflatoxin\r\nexposure in populations, dietary sources of contamination and household dietary\r\npractices leading to frequent food contamination in order to identify high risk groups\r\nand to develop preventive interventions to mitigate human exposure to aflatoxins.\r\nAflatoxins in human body are metabolized by the liver enzymes and produces\r\naflatoxin 8,9-epoxide, which reacts with albumin in the liver to form AFB1-albumin\r\nadducts that are major biomarkers found in peripheral blood. In order to protect human\r\nhealth it is important to be able to estimate aflatoxin-albumin adduct in human blood.\r\nAmong many methods available for estimation immunochemical methods are simple,\r\ncost effective and adaptable to situations in developing countries. Hence this study is\r\nproposed to assess the aflatoxin exposure in Indian populations using ELISA which\r\nwill lead to the development of preventive interventions to minimize the risk of liver\r\ndisorders and HCC.\r\nThis thesis is divided into 9 chapters containing subsections. Chapter 1 and chapter 2\r\ncontains the introduction and review of literature. Chapter 3 contains materials and\r\nmethods for the development of antibodies to detect aflatoxin-albumin adduct in\r\nhuman blood samples. Chapter 4 contains Results. Chapter 5 and 6 contains\r\ndiscussion, summary and conclusion. Chapter 7 contains references, Chapter 8\r\ncontains appendix and Chapter 9 contains Annexure I, II and Master charts."^^ . "2011" . . . . "Nizam’s Institute of Medical Sciences"^^ . . . "Department of Medical Oncology, Nizam’s Institute of Medical Sciences"^^ . . . . . . . . "S"^^ . "Anitha"^^ . "S Anitha"^^ . . . . . . "Assessment of Aflatoxin Exposure among Indian Population (PDF)"^^ . . . . . "Assessment of Aflatoxin Exposure among Indian Population (Indexer Terms)"^^ . . . . . . "Assessment of Aflatoxin Exposure among Indian Population (Image (PNG))"^^ . . . . . . "Assessment of Aflatoxin Exposure among Indian Population (Image (PNG))"^^ . . . . . . "Assessment of Aflatoxin Exposure among Indian Population (Image (PNG))"^^ . . . . . . "Assessment of Aflatoxin Exposure among Indian Population (Image (PNG))"^^ . . . . . "HTML Summary of #5268 \n\nAssessment of Aflatoxin Exposure among Indian Population\n\n" . "text/html" . . . "Plant Pathology"@en . . . "Plant Virology"@en . . . "Agriculture-Farming, Production, Technology, Economics"@en . .