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        <dc:title>Discovery and validation of candidate genes for grain iron and zinc metabolism in pearl millet [Pennisetum glaucum (L.) R. Br.]</dc:title>
        <dc:creator>Mahendrakar, M D</dc:creator>
        <dc:creator>Parveda, M</dc:creator>
        <dc:creator>Kishor, P B K</dc:creator>
        <dc:creator>Srivastava, R K</dc:creator>
        <dc:subject>Pearl Millet</dc:subject>
        <dc:subject>Genetics and Genomics</dc:subject>
        <dc:subject>Food and Nutrition</dc:subject>
        <dc:description>Pearl millet is an important crop for alleviating micronutrient malnutrition through genomics-assisted&#13;
breeding for grain Fe (GFeC) and Zn (GZnC) content. In this study, we identified candidate genes&#13;
related to iron (Fe) and zinc (Zn) metabolism through gene expression analysis and correlated it with&#13;
known QTL regions for GFeC/GZnC. From a total of 114 Fe and Zn metabolism-related genes that were&#13;
selected from the related crop species, we studied 29 genes. Different developmental stages exhibited&#13;
tissue and stage-specific expressions for Fe and Zn metabolism genes in parents contrasting for GFeC&#13;
and GZnC. Results revealed that PglZIP, PglNRAMP and PglFER gene families were candidates for&#13;
GFeC and GZnC. Ferritin-like gene, PglFER1 may be the potential candidate gene for GFeC. Promoter&#13;
analysis revealed Fe and Zn deficiency, hormone, metal-responsive, and salt-regulated elements.&#13;
Genomic regions underlying GFeC and GZnC were validated by annotating major QTL regions for grain&#13;
Fe and Zn. Interestingly, PglZIP and PglNRAMP gene families were found common with a previously&#13;
reported linkage group 7 major QTL region for GFeC and GZnC. The study provides insights into the&#13;
foundation for functional dissection of different Fe and Zn metabolism genes homologs and their&#13;
subsequent use in pearl millet molecular breeding programs globally.</dc:description>
        <dc:publisher>Nature Research</dc:publisher>
        <dc:date>2020-10</dc:date>
        <dc:type>Article</dc:type>
        <dc:type>PeerReviewed</dc:type>
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        <dc:language>en</dc:language>
        <dc:identifier>http://oar.icrisat.org/11647/1/s41598-020-73241-7.pdf</dc:identifier>
        <dc:identifier>  Mahendrakar, M D and Parveda, M and Kishor, P B K and Srivastava, R K  (2020) Discovery and validation of candidate genes for grain iron and zinc metabolism in pearl millet [Pennisetum glaucum (L.) R. Br.].  Scientific Reports (TSI), 10 (1).   ISSN 2045-2322     </dc:identifier>
        <dc:relation>https://doi.org/10.1038/s41598-020-73241-7</dc:relation>
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