TY  - JOUR
AV  - public
A1  - Pandey, A K
A1  - Sudini, H
A1  - Upadhyaya, H D
A1  - Varshney, R K
A1  - Pandey, M K
TI  - Hypoallergen Peanut Lines Identified Through Large-Scale Phenotyping of Global Diversity Panel: Providing Hope Toward Addressing One of the Major Global Food Safety Concerns
UR  - https://doi.org/10.3389/fgene.2019.01177
JF  - Frontiers in Genetics (TSI)
SN  - 1664-8021
PB  - Frontiers Media
N1  - The authors are thankful to partial financial assistance from Indian Council of Agricultural Research (ICAR) and Department of Biotechnology (DBT), India. We acknowledge Sunil S. Gangurde for performing the cluster analysis. The work reported in this article was undertaken as part of the CGIAR Research Program on Grain Legumes and Dryland Cereals (CRP-GLDC). ICRISAT is a member of CGIAR Consortium.
N2  - Peanut allergy is one of the serious health concern and affects more than 1% of the
world?s population mainly in Americas, Australia, and Europe. Peanut allergy is sometimes
life-threatening and adversely affect the life quality of allergic individuals and their families.
Consumption of hypoallergen peanuts is the best solution, however, not much effort has
been made in this direction for identifying or developing hypoallergen peanut varieties.
A highly diverse peanut germplasm panel was phenotyped using a recently developed
monoclonal antibody-based ELISA protocol to quantify five major allergens. Results
revealed a wide phenotypic variation for all the five allergens studied i.e., Ara h 1 (4?36,833
?g/g), Ara h 2 (41?77,041 ?g/g), Ara h 3 (22?106,765 ?g/g), Ara h 6 (829?103,892 ?g/g),
and Ara h 8 (0.01?70.12 ?g/g). The hypoallergen peanut genotypes with low levels of
allergen proteins for Ara h 1 (4 ?g/g), Ara h 2 (41 ?g/g), Ara h 3 (22 ?g/g), Ara h 6 (829 ?g/g), and Ara h 8 (0.01 ?g/g) have paved the way for their use in breeding and
genomics studies. In addition, these hypoallergen peanut genotypes are available for use in cultivation and industry, thus opened up new vistas for fighting against peanut allergy problem across the world.
KW  - Reference set
KW  -  Peanut Allergens
KW  -  Ara h 1
KW  -  Ara h 2
KW  -  Ara h 3
KW  -  Ara h 6
KW  -  Ara h 8
KW  -  enzyme-linked immunosorbent assay
Y1  - 2019/11//
SP  - 1
ID  - icrisat11345
EP  - 15
VL  - 10
IS  - 1177
ER  -