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dc:title "HTML Summary of #10301 \n\nHarnessing Benefits of Finger Millet in Combating Micronutrient Malnutrition through Genetics and Genomic Approaches\n\n";
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bibo:abstract "In developing countries, 80% deaths are attributed to continuous persistence micronutrient deficiency and associated\r\ninfections and chronic diseases. Traditional crops harbouring health benefitting characteristics and micronutritional\r\nrichness can deliver a low cost sustainable food-based solution for nutrition and health in such countries. Finger\r\nmillet, one such traditional crop grown in most marginal areas of Africa and Asia, is a rich source of health\r\nbenefitting micronutrients, phytochemicals, vitamins and several essential amino acids. The objective of this work\r\nis to use advances in genetics and genomics approaches for better understanding the genetic control of these\r\nhealth benefitting traits and to breed them effectively into other staple crops consumed on daily basis. A set of\r\n190 genotypes incorporating a minicore collection of finger millet together with a number of elite breeding lines\r\nhas been assembled to capture and characterise entire genetic variation associated with such traits in the crop\r\ngermplasm. These genotypes have been extensively characterised for diversity in micronutrients (such as iron,\r\nzinc, calcium, magnesium, sodium, and potassium), protein and anti-nutrients (phytate and oxalate). Large-scale\r\nGBS performed on this association panel has generated 156,157 SNPs which are being used in genome-wide\r\nassociation studies. Our work has identified a number of genomic regions in finger millet associated with both\r\nthe health benefitting traits as well as with other factors that affect their bioavailability. This work will significantly\r\ncontribute in developing means of assessing how such genetic variations are distributed in other staple crops."^^xsd:string;
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