<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability"^^ . "Oilseed crops such as maize and peanut are staple food crops\r\nwhich are vital for global food security. The contamination of\r\nthese crops with carcinogenic aflatoxins during infection by Aspergillus\r\nflavus under drought stress conditions is a serious threat\r\nto the safety of these commodities. In order to better understand\r\nthe role of aflatoxin production in the biology of this pathogen\r\nunder environmental stress, a collaborative transcriptome project\r\nwas undertaken to examine the transcriptional responses of\r\ntoxigenic and atoxigenic isolates of A. flavus to oxidative stress.\r\nSelected isolates were cultured in aflatoxin production-conducive\r\nand non-conducive media amended with varying levels of\r\nH2O2. Isolates which possessed greater tolerance to H2O2\r\nstress and aflatoxin production capability exhibited fewer differentially\r\nexpressed genes (DEGs) than those which possessed\r\nless tolerance and lower aflatoxin production. Primary metabolic\r\nmechanisms were also stimulated in response to stress along\r\nwith antioxidant enzyme-encoding genes. Genes related to\r\nfungal development such as aminobenzoate degradation genes\r\nand conidiation regulators were also differentially expressed\r\nin response to stress. Secondary metabolite biosynthetic processes\r\nalso formed a large component of the isolate responses\r\nto stress including those for aflatoxin, aflatrem, and kojic acid.\r\nCo-expression analyses also showed that aflatoxin biosynthetic\r\ngene expression along with antioxidant genes were highly correlated\r\nwith toxigenic isolate biomass under variable stresses.\r\nThese results along with others in the literature suggest that the\r\nproduction of these secondary metabolites may provide supplemental\r\noxidative stress alleviation. Additional data validation using\r\nproteomics, metabolomics and whole genome resequencing\r\n(WGRS) approaches will also be discussed."^^ . "2017-02" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "V"^^ . "Kumar"^^ . "V Kumar"^^ . . "P"^^ . "Bajaj"^^ . "P Bajaj"^^ . . "L"^^ . "Yang"^^ . "L Yang"^^ . . "B T"^^ . "Scully"^^ . "B T Scully"^^ . . "M K"^^ . "Pandey"^^ . "M K Pandey"^^ . . "J C"^^ . "Fountain"^^ . "J C Fountain"^^ . . "R K"^^ . "Varshney"^^ . "R K Varshney"^^ . . "A S"^^ . "Jayale"^^ . "A S Jayale"^^ . . "R D"^^ . "Lee"^^ . "R D Lee"^^ . . "B"^^ . "Guo"^^ . "B Guo"^^ . . "A"^^ . "Chitikineni"^^ . "A Chitikineni"^^ . . "R C"^^ . "Kemerait"^^ . "R C Kemerait"^^ . . . . "InterDrought-V"^^ . . . . . "Hyderabad, India"^^ . . . . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (PDF)"^^ . . . . . "Abstract_Book_120.pdf"^^ . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (Other)"^^ . . . . . . "small.jpg"^^ . . . "Drought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus\r\nto oxidative stress are related to stress tolerance and aflatoxin production capability (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #10290 \n\nDrought stress and aflatoxin contamination: transcriptional responses of Aspergillus flavus \nto oxidative stress are related to stress tolerance and aflatoxin production capability\n\n" . "text/html" . . . "Groundnut"@en . . . "Oilseeds"@en . . . "Aflatoxins"@en . .