Anticlastogenic potential of pigeonpea (Cajanus cajan (L.) Millsp.) in white mice (Mus musculus L.)

Sanchez, G C and Tanquilut, N C and Tanquilut, M R C and Soriano Junior, H R and Mula, M G and Mula, R P (2016) Anticlastogenic potential of pigeonpea (Cajanus cajan (L.) Millsp.) in white mice (Mus musculus L.). Green Farming, 07 (02). pp. 357-360. ISSN 0974-0775

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Abstract

This study investigated the anticlastogenic potential of International Crop Research Institute for Semi-Arid Tropics (ICRISAT) bred pigeonpea utilizing the micronudeus test using white mice models to determine the number of micronucleated polychromatic erythrocytes (MPCEs) in treated and non-treated white mice at the Pampanga State Agricultural University (PSAU), Magalang, Pampanga, Philippines. Furthermore, the study disclose if pigeonpea has detrimental effects on the vital signs and some vital organs such as lungs, heart, liver, kidney and intestine. Based on the study, pigeonpea ICPL 87051 leaves decoction have anticlastogenic effects. This might be attributed to the presence of flavonoids, tannins and stilbenes in pigeonpea leaves that has the ability to lower MPCEs in treated and non-treated white mice. In terms of its effects on the vital signs namely heart rate, respiratory rate and temperature, results showed that pigeonpea did not cause heart palpitation, tachycardia, hyperpnea and hypothermia. Treatments T+ (Positive control, TCN) and T2 (Pigeonpea leaves extract of 0.5 per 20 kg body weight + TCN) have normal heart, liver, kidney, lungs and intestines.

Item Type: Article
Divisions: RP-Grain Legumes
CRPS: CGIAR Research Program on Grain Legumes
Uncontrolled Keywords: Anticlastogenic, Micronucleated polychromatic erythrocytes, Pigeonpea, White mice
Subjects: Mandate crops > Pigeonpea
Depositing User: Mr Ramesh K
Date Deposited: 20 Apr 2016 08:22
Last Modified: 20 Apr 2016 08:25
URI: http://oar.icrisat.org/id/eprint/9443
Official URL: http://www.greenfarming.in/?articles=anticlastogen...
Projects: UNSPECIFIED
Funders: UNSPECIFIED
Acknowledgement: The authors would like to acknowledge DA-Bureau of Agricultural Research (DA-BAR) for funding this project and the International Crop Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Telangana, India for the pigeonpea variety ICPL 87051 and Pampanga Agricultural College for the smooth implementation ofthis research.
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