Srivastava, A and Varshney, R K and Shukla, P (2020) Sigma Factor Modulation for Cyanobacterial Metabolic Engineering. Trends in Microbiology, 29 (3). pp. 266-277. ISSN 0966-842X
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Sigma (σ) factors are key regulatory proteins that control the transcription initiation in prokaryotes. In response to environmental or developmental cues, σ factors initiate the transcription of necessary genes responsible for maintaining a life-sustaining metabolic balance. Due to the significant role of σ factors in bacterial metabolism, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacterial cells is a desirable venture. As cyanobacterial genomes typically encode multiple σ factors, effective execution of metabolic engineering efforts largely relies on uncovering the complicated gene regulatory network and further characterization of the members of σ factor regulatory circuits. This review outlines the prospects of σ factor in metabolic engineering of cyanobacteria, summarizes the challenges in the path towards an efficient strain construction and highlights the genomic context of putative regulators of cyanobacterial σ factors.
| Item Type: | Article |
|---|---|
| Divisions: | Center of Excellence in Genomics and Systems Biology |
| CRP: | UNSPECIFIED |
| Uncontrolled Keywords: | sigma factor, metabolic engineering, cyanobacteria, glycogen |
| Subjects: | Others > Genetics and Genomics |
| Depositing User: | Mr Nagaraju T |
| Date Deposited: | 04 Jun 2025 03:49 |
| Last Modified: | 04 Jun 2025 03:49 |
| URI: | http://oar.icrisat.org/id/eprint/13111 |
| Official URL: | https://www.cell.com/trends/microbiology/abstract/... |
| Projects: | UNSPECIFIED |
| Funders: | UNSPECIFIED |
| Acknowledgement: | UNSPECIFIED |
| Links: |
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