Crisp, P A and Bhatnagar-Mathur, P and Hundleby, P and Godwin, I D and Waterhouse, P M and Hickey, L T (2021) Beyond the gene: epigenetic and cis-regulatory targets offer new breeding potential for the future. Current Opinion in Biotechnology, 73. pp. 88-94. ISSN 0958-1669
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For millennia, natural and artificial selection has combined favourable alleles for desirable traits in crop species. While modern plant breeding has achieved steady increases in crop yields over the last century, on the current trajectory we will simply not meet demand by 2045. Novel breeding strategies and sources of genetic variation will be required to sustainably fill predicted yield gaps and meet new consumer preferences. Here, we highlight that stepping up to meet this grand challenge will increasingly require thinking ‘beyond the gene’. Significant progress has been made in understanding the contributions of both epigenetic variation and cis-regulatory variation to plant traits. This non-genic variation has great potential in future breeding, synthetic biology and biotechnology applications.
| Item Type: | Article |
|---|---|
| Divisions: | Global Research Program - Accelerated Crop Improvement |
| CRP: | UNSPECIFIED |
| Uncontrolled Keywords: | plant breeding, epigenetics, cis-regulatory elements, DNA methylation, crops, CRISPR, gene editing, epiallele |
| Subjects: | Others > Biotechnology Others > Genetic Engineering Others > Plant Breeding |
| Depositing User: | Mr Nagaraju T |
| Date Deposited: | 26 Mar 2024 09:11 |
| Last Modified: | 26 Mar 2024 09:11 |
| URI: | http://oar.icrisat.org/id/eprint/12600 |
| Official URL: | https://www.sciencedirect.com/science/article/abs/... |
| Projects: | UNSPECIFIED |
| Funders: | UNSPECIFIED |
| Acknowledgement: | P.A.C. is the recipient of an Australian Research Council (ARC) Discovery Early Career Award (project number DE200101748) funded by the Australian Government. P.H. acknowledges funding support from the Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Programmes GEN [BB/P013511/1] to the John Innes Centre. P.M.W. is a recipient of an ARC Laureate Fellowship (FL160100155) and acknowledges funding from the ARC Centre of Excellence for Plant Success in Nature and... |
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