Addressing Iron and Zinc Micronutrient Malnutrition Through Nutrigenomics in Pearl Millet: Advances and Prospects

Srivastava, R K and Satyavathi, C T and Mahendrakar, M D and Singh, R B and Kumar, S and Govindaraj, M and Ghazi, I A (2021) Addressing Iron and Zinc Micronutrient Malnutrition Through Nutrigenomics in Pearl Millet: Advances and Prospects. Frontiers in Genetics (TSI), 12 (723472). pp. 1-9. ISSN 1664-8021

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Abstract

Iron (Fe) and zinc (Zn) micronutrient deficiencies are significant health concerns, particularly among the underprivileged and resource-poor people in the semi-arid tropics globally. Pearl millet is regarded as a climate-smart crop with low water and energy footprints. It thrives well under adverse agro-ecologies such as high temperatures and limited rainfall. Pearl millet is regarded as a nutri-cereal owing to health-promoting traits such as high grain Fe and Zn content, metabolizable energy, high antioxidant and polyphenols, high proportion of slowly digestible starches, dietary fibers, and favorable essential amino acid profile compared to many cereals. Higher genetic variability for grain Fe and Zn content has facilitated considerable progress in mapping and mining QTLs, alleles and genes underlying micronutrient metabolism. This has been made possible by developing efficient genetic and genomic resources in pearl millet over the last decade. These include genetic stocks such as bi-parental RIL mapping populations, association mapping panels, chromosome segment substitution lines (CSSLs) and TILLING populations. On the genomics side, considerable progress has been made in generating genomic markers, such as SSR marker repository development. This was followed by the development of a next-generation sequencing-based genome-wide SNP repository. The circa 1,000 genomes re-sequencing project played a significant role. A high-quality reference genome was made available by re-sequencing of world diversity panel, mapping population parents and hybrid parental lines. This mini-review attempts to provide information on the current developments on mapping Fe and Zn content in pearl millet and future outlook.

Item Type:	Article
Divisions:	Global Research Program - Accelerated Crop Improvement
CRP:	CGIAR Research Program on Grain Legumes and Dryland Cereals (GLDC)
Uncontrolled Keywords:	Micronutrient malnutrition, Iron and zinc deficiency, Pearl millet [Pennisetum glaucum (L.) R. Br.], Nextgeneration sequencing (NGS), Forward genetics, Reverse genetics
Subjects:	Mandate crops > Millets > Pearl Millet Others > Food and Nutrition
Depositing User:	Mr Arun S
Date Deposited:	19 Nov 2021 05:22
Last Modified:	19 Nov 2021 05:22
URI:	http://oar.icrisat.org/id/eprint/11927
Official URL:	https://doi.org/10.3389/fgene.2021.723472
Projects:	UNSPECIFIED
Funders:	UNSPECIFIED
Acknowledgement:	Funding support from the Department of Biotechnology (DBT) and the CGIAR Research Program on Dryland Cereals is gratefully acknowledged. This work has been published as part of the CGIAR Research Program on Dryland Cereals.
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