Pazhamala, L T and Kudapa, H and Weckwerth, W and Millar, A H and Varshney, R K (2021) Systems biology for crop improvement. The Plant Genome (TSI). pp. 1-23. ISSN 1940-3372
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Abstract
In recent years, generation of large-scale data fromgenome, transcriptome, proteome, metabolome, epigenome, and others, has become routine in several plant species. Most of these datasets in different crop species, however, were studied independently and as a result, full insight could not be gained on the molecular basis of complex traits and biological networks. A systems biology approach involving integration of multiple omics data, modeling, and prediction of the cellular functions is required to understand the flow of biological information that underlies complex traits. In this context, systems biology with multiomics data integration is crucial and allows a holistic understanding of the dynamic system with the different levels of biological organization interactingwith external environment for a phenotypic expression. Here, we present recent progress made in the area of various omics studies—integrative and systems biology approaches with a special focus on application to crop improvement. We have also discussed the challenges and opportunities in multiomics data integration, modeling, and understanding of the biology of complex traits underpinning yield and stress tolerance in major cereals and legumes.
| Item Type: | Article |
|---|---|
| Divisions: | Research Program : Genetic Gains |
| CRP: | CGIAR Research Program on Grain Legumes and Dryland Cereals (GLDC) |
| Uncontrolled Keywords: | Genetics, Genomics |
| Subjects: | Others > Genetics and Genomics |
| Depositing User: | Mr Arun S |
| Date Deposited: | 24 May 2021 16:03 |
| Last Modified: | 24 May 2021 16:03 |
| URI: | http://oar.icrisat.org/id/eprint/11814 |
| Official URL: | https://doi.org/10.1002/tpg2.20098 |
| Projects: | UNSPECIFIED |
| Funders: | UNSPECIFIED |
| Acknowledgement: | This review describes several studies that have been undertaken at ICRISAT as part of the Systems Biology Research Initiative from ICRISAT. RKV is thankful to Science & Engineering Research Board (SERB) of Department of Science & Technology (DST), Government of India for providing the J C Bose National Fellowship (SB/S9/Z-13/2019) and Bill & Melinda Gates Foundation and CGIAR Research Program on Grain Legumes and Dryland Cereals (GLDC) for supporting the research activities at CEGSB. HK acknowledges the SERB of DST, Government of India for providing the SERB Women Excellence Award (SB/WEA-01/2017). ICRISAT is a member of CGIAR Consortium. |
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