Aflatoxin-lysine adducts in blood serum of the Malawian rural population and aflatoxin contamination in foods (groundnuts, maize) in the corresponding areas

Anitha, S and Monyo, E S and Tsusaka, T W and Msere, H W and Madinda, F and Chilunjika, T and Sichone, E and Mbughi, D and Chilima, B and Matumba, L (2018) Aflatoxin-lysine adducts in blood serum of the Malawian rural population and aflatoxin contamination in foods (groundnuts, maize) in the corresponding areas. Mycotoxin Research (TSI), 34 (3). pp. 195-204. ISSN 0178-7888

[img] PDF - Published Version
Restricted to ICRISAT users only

Download (766kB) | Request a copy

Abstract

Aflatoxin-lysine (AFB1-lys) adduct levels in blood samples collected from 230 individuals living in three districts of Malawi (Kasungu, Mchinji, and Nkhotakota) and aflatoxin B1 (AFB1) levels in groundnut and maize samples collected from their respective homesteads were determined using indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) methods. AFB1-lys adducts were detected in 67% of blood samples, with a mean concentration of 20.5 ± 23.4 pg/mg of albumin. AFB1 was detected in 91% of groundnut samples and in 70% of maize samples, with mean AFB1 levels of 52.4 and 16.3 μg/kg, respectively. All participants of this study reported consuming maize on a daily basis and consuming groundnuts regularly (mean consumption frequency per week: 3.2 ± 1.7). According to regression analysis, a frequency of groundnut consumption of more than four times per week, being female, and being a farmer were significant (p < 0.05) contributors to elevated AFB1-lys adduct levels in the blood. This is the first report on AFB1-lys adducts in blood samples of residents in Malawi. The results reinforce the urgent need for interventions, aiming at a reduction of aflatoxin exposure of the population.

Item Type: Article
Divisions: Research Program : East & Southern Africa
CRP: CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
Uncontrolled Keywords: Aflatoxin-lysine, Malawi, aflatoxins, groundnut, maize, blood samples, exposure, women farmers, rural population, blood samples, AFB
Subjects: Mandate crops > Groundnut
Others > Maize
Others > African Agriculture
Others > Aflatoxins
Others > Malawi
Depositing User: Mr Ramesh K
Date Deposited: 07 Aug 2018 07:55
Last Modified: 07 Aug 2018 07:55
URI: http://oar.icrisat.org/id/eprint/10824
Official URL: http://dx.doi.org/10.1007/s12550-018-0314-5
Projects: UNSPECIFIED
Funders: McKnight Foundation & CGIAR Research Program on Agriculture for Nutrition and Health (CRPA4NH)
Acknowledgement: The authors thank the National Health Science Research Committee (NHSRC), Malawi, for permitting the implementation of this study. Funding information This study was financially supported by the McKnight Foundation (USA) and the CGIAR Research Program on Agriculture for Nutrition and Health (CRPA4NH).
Links:

Actions (login required)

View Item View Item